He talks about how he got inspired for the game, like with the movie Powers of 10 or 2001 and other science fiction books and films. Wright is also interested in the SETI project.
With Spore, he tries to give players an "awe-inspiring global view of reality, almost like a drug-induced epiphany with a computer." The game will have to bring you to theological discussions, or philosophy, while remaining playable and fun. There won't really be any religion in the game, though it can be left to the imagination of the player. The Cultural way is one way to conquer other civilisations, and is possibly psuedo-religious.
The name SimEverything is a name that was the first choice for Will, though by now he's started liking Spore more and more. It's also refreshing that he didn't put the Sim bit in front of it.
Wright likes the animation the most, as it's something entirely new. The procedural animation is something the team has done a lot of research on, as it's an entirely new technology. As for user-created content he says that it has two benefits. The first one is that the player is attached to it, as it's his own creation. As shown with the Sims, people love sharing and trading their stuff, which is the second advantage. With the procedural techniques, the developers can give both the player and the game itself a lot of creative leverage.
Finally there's already some talk about what an expansion would be like. Wright wants to expand it more broadly rather than deeply. That means he would like to take parts, and bring it to people who never bought the original game, but will be using a part of it.
The interview is of course more detailed than this summary, so read it for the exact details.