With the title "The most incredible game ever?" GamesRadar has posted a preview of Spore, which was shown behind closed doors at the E3. Although most of the information is known, and there's nothing really new in the preview, it does more or less seem to confirm that a connection to the internet is not absolutely necesary:

"The computer will randomly generate species and, considering the sheer size and scale of the game, you could be seeing new creatures on new planets in this game for the rest of your life - this really will be the game that will never end."

The article also says Spore is developed for PC, but any of the consoles are not mentioned. Read the article for the exact details, and GameRadar's enthousiasm.